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Goldenseal
Hydrastis canadensis
Anti-tumourmoderate evidence
Goldenseal's primary active compound is berberine — one of the most studied natural anti-cancer molecules. Berberine activates AMPK, inhibits mTOR, reduces glucose uptake in cancer cells, and induces apoptosis in multiple cancer types. Goldenseal also provides hydrastine and canadine with additional antimicrobial effects relevant for gut health.
Medicinal Properties
Anti-tumourAntimicrobialImmunomodulatoryAnti-inflammatoryBerberine-rich
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Cancer Types Studied
ColonBreastLiverLungGastric
Recommended Dosage
500–1000 mg standardised goldenseal extract daily.
Preparations
Capsules
500–1000 mg standardised goldenseal root extract daily with meals.
NIH / PubMed Research
Links open on PubMed (National Library of Medicine). Research is ongoing — results may not reflect clinical use.
Cautions & Interactions
- Do not use in pregnancy — stimulates uterine contractions
- May interact with cytochrome P450 metabolised drugs
- Do not use long-term without breaks
- May lower blood sugar — monitor in diabetics
Related Herbs
Informational only. Not medical advice. Consult your healthcare provider before use.