iOnco
Cancer Vaccines

Cancer Vaccines

From approved HPV vaccines preventing millions of cancers, to personalised mRNA programs and the EU's vaccine accelerator — the complete global landscape.

4 Approved2 In Phase 34 Personalised mRNA22 Cancers Targeted
ApprovedPhase 3Phase 2Phase 1Preclinical
11 vaccines

Off-Label Drug Use — Consult Your Doctor

Information about repurposed drugs describes off-label uses that are not approved by regulatory agencies. This is not a recommendation to take any drug.

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Gardasil 9

Merck (MSD)

Approved
PreventiveUS / Global
CervicalAnalOropharyngealVulvar+2 more

Availability: Available now — recommended ages 9–45 (US), 9–26 primary schedule

6 key trial results · 3 references
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💉

Cervarix

GlaxoSmithKline (GSK)

Approved
PreventiveUK / Global
CervicalAnalOropharyngeal

Availability: Available now — used in many EU national immunisation programs

5 key trial results · 2 references
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🛡️

Hepatitis B Vaccine

Multiple (GSK, Merck, Dynavax)

Approved
PreventiveGlobal
Hepatocellular Carcinoma (Liver Cancer)

Availability: Available now — included in standard infant vaccination schedule globally

5 key trial results · 2 references
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🧬

mRNA-4157 / V940

Moderna + Merck (MSD)

Phase 3
Personalised mRNAUS / EU
MelanomaNon-Small Cell Lung CancerBladder CancerColorectal Cancer

Availability: Potentially 2026–2027 if Phase 3 succeeds; FDA Breakthrough pathway

7 key trial results · 3 references
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🔬

BNT122 (Autogene Cevumeran)

BioNTech + Genentech (Roche)

Phase 2
Personalised mRNAGermany / EU / US
Pancreatic Ductal Adenocarcinoma (PDAC)Colorectal CancerMelanoma

Availability: Phase 2 ongoing — potential availability 2027–2028 if trials succeed

6 key trial results · 2 references
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🧪

BNT111

BioNTech

Phase 2
TherapeuticGermany / EU
Melanoma

Availability: Phase 2 — potential availability 2027+ if trials succeed

5 key trial results · 2 references
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🇷🇺

Russian mRNA Cancer Vaccine

Gamaleya National Research Centre for Epidemiology and Microbiology + N.N. Blokhin National Medical Research Centre of Oncology

Phase 1
Personalised mRNARussia
MelanomaLung CancerColorectal CancerBreast Cancer+2 more

Availability: Phase 1 trials now — broader availability 2027+ if efficacy proven

5 key trial results · 1 references
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🇪🇺

EU Cancer Vaccines Accelerator

European Commission + BioNTech + multiple EU research centres

Phase 2
Personalised mRNAEU
MelanomaLung CancerColorectal CancerBreast Cancer+2 more

Availability: Infrastructure being built 2024–2026; vaccine access under clinical trials in EU hospitals now; broader access 2027+

7 key trial results · 2 references
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🧠

DCVax-L

Northwest Biotherapeutics

Phase 3
Dendritic CellUS / EU (UK trial sites)
Glioblastoma (GBM)Brain Cancer

Availability: UK: MHRA reviewing; EU: EMA engagement ongoing. US: not yet FDA-approved. Compassionate use in some EU centres.

7 key trial results · 2 references
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💊

Provenge (Sipuleucel-T)

Dendreon (now Valeant / Sanofi)

Approved
Dendritic CellUS
Prostate Cancer (metastatic castration-resistant)

Availability: Available now in the US for eligible prostate cancer patients

6 key trial results · 2 references
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🫁

BNT116

BioNTech

Phase 1
TherapeuticGermany / EU / UK
Non-Small Cell Lung Cancer (NSCLC)

Availability: Phase 1 — earliest 2028+ if Phase 3 initiated promptly

5 key trial results · 2 references
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