Therapeutic Peptides

Thymosin Alpha-1 (Tα1) is a 28-amino-acid peptide naturally secreted by the thymus. It is one of the most clinically researched peptides in oncology — licensed in over 35 countries as Zadaxin® for use alongside cancer chemotherapy and as an antiviral. It restores immune competence in immunosuppressed patients, particularly those undergoing cytotoxic treatment.

BPC-157 is a synthetic 15-amino-acid peptide derived from a protein found in human gastric juice. It has remarkable tissue-healing properties in pre-clinical studies — healing gut mucosa, tendons, ligaments, nerves, and muscle. In cancer-care contexts it is used to manage chemotherapy-induced gut toxicity, NSAID damage, and radiation enteritis.

GHK-Cu is a naturally occurring copper-binding tripeptide present in human blood at high concentration in youth (~200 ng/mL at age 20) and declining sharply with age (~80 ng/mL by age 60). It has broad tissue-remodelling, anti-inflammatory, and — uniquely — significant gene-regulation properties that have drawn oncology research interest.

Epithalon is a synthetic tetrapeptide developed by the St. Petersburg Institute of Bioregulation and Gerontology. It mimics Epithalamin — a natural pineal extract used in decades of Russian anti-ageing research. It is the only substance demonstrated to activate telomerase in somatic cells, extending telomere length, which has implications for both longevity and cancer biology.

MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA — one of a new class of 'mitokines' that act as metabolic stress signals. It circulates in the blood, responds to exercise and fasting, and regulates whole-body metabolism. Research interest in oncology centres on its ability to normalise cancer metabolism (Warburg effect) and sensitise cancer cells to chemotherapy.

LL-37 is the only human cathelicidin — a 37-amino-acid host-defence peptide cleaved from the precursor protein hCAP-18. It is part of the innate immune system and is expressed in response to infection, injury, and inflammation. It has direct antimicrobial activity and, uniquely, direct cancer cell-killing activity via membrane disruption — but its role in cancer is complex and context-dependent.

Thymalin is a polypeptide complex extracted from the thymus gland of young calves. Developed in Russia by the same team behind Epithalon, it has been used clinically for decades in post-Soviet medicine alongside oncology treatment. Unlike Thymosin Alpha-1 (a single peptide), Thymalin is a broader thymic extract containing multiple bioregulatory peptides.

Selank is a synthetic anxiolytic and nootropic peptide developed by the Russian Academy of Sciences as a stable analogue of Tuftsin (an endogenous immunopeptide from IgG). It is approved in Russia and Ukraine for anxiety and asthenia. In cancer care it is used to manage chemotherapy-related cognitive impairment ('chemo brain'), anxiety, and immune dysregulation.

Thymosin Beta-4 (and its active fragment TB-500) is one of the most abundant intracellular peptides in the human body. It sequesters actin monomers, regulates cytoskeletal dynamics, and plays a central role in tissue repair, wound healing, and inflammation resolution. In cancer care it is used to accelerate surgical wound healing, repair radiation-damaged tissue, and reduce treatment-associated inflammation.

Humanin is a 21-amino-acid peptide encoded within mitochondrial DNA, discovered in 2001 as a survival factor that protects neurons from Alzheimer's-associated cell death. It is part of the same family as MOTS-c — mitochondria-derived peptides (MDPs) that act as endocrine signals coordinating metabolic stress responses. Blood levels decline with age and are reduced in cancer patients.