iOnco
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Japanese Knotweed / Resveratrol

Reynoutria japonica

Anti-tumourmoderate evidence

Japanese knotweed is the richest plant source of resveratrol — a potent polyphenol studied in thousands of cancer research papers. Resveratrol activates SIRT1, inhibits NF-κB, induces apoptosis across multiple cancer types, reduces angiogenesis, and shows synergy with conventional chemotherapy. Trans-resveratrol from knotweed root is the most bioactive form.

Medicinal Properties

Anti-tumourAntioxidantAnti-inflammatoryAnti-angiogenicPhytoestrogenic
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Cancer Types Studied

BreastColonProstateLungLeukemia

Recommended Dosage

250–500 mg trans-resveratrol daily from standardised Japanese knotweed extract.

Preparations

Trans-Resveratrol Capsules

250–500 mg trans-resveratrol daily (standardised from Japanese knotweed root). Take with food and healthy fats for absorption.

NIH / PubMed Research

Links open on PubMed (National Library of Medicine). Research is ongoing — results may not reflect clinical use.

Cautions & Interactions

  • May interact with blood-thinning medications at high doses
  • High doses may act as phytoestrogen — caution in ER+ cancers
  • Bioavailability is low — liposomal or micronised forms preferred
  • May interact with cytochrome P450 enzymes

Informational only. Not medical advice. Consult your healthcare provider before use.