Insulin Potentiation Therapy (IPT)
IPT uses insulin to exploit cancer cells' overexpression of insulin receptors (IR) and IGF-1 receptors. A bolus of insulin drives blood glucose to 40–50 mg/dL (hypoglycaemic window), causing cancer cells to upregulate membrane receptors and open glucose transport channels — at this moment, low-dose chemotherapy (10–15% of standard dose) is administered IV. The theory: cancer cells in a nutrient-deprived, high-receptor state absorb dramatically more drug than normal cells.
Mechanism of Action
Cancer cells overexpress insulin receptors (up to 10x normal cells) as they depend heavily on glucose. When insulin creates a hypoglycaemic state, cancer cells upregulate glucose transporters (GLUT) and increase membrane permeability — in this 'thirsty' state, the entire 10–15% low-dose chemotherapy is theoretically absorbed preferentially by cancer cells. Proponents claim equal or better tumour response with dramatically fewer side effects due to the reduced drug dose.
Cancer Types Studied
Protocols & Dosing
Standard IPT Protocol
IV insulin (15–25 units) administered, blood glucose monitored until 40–50 mg/dL. At this point, low-dose chemo (10–15% standard dose) given IV immediately. Glucose dextrose given after to reverse hypoglycaemia. Weekly sessions at specialised IPT clinic.
NIH / PubMed Research
Links open on PubMed (National Library of Medicine). Research is ongoing — results may not reflect clinical use.
Cautions & Contraindications
- Risk of severe hypoglycaemia — requires emergency glucose administration, medical monitoring, IV access
- Contraindicated in diabetes, adrenal insufficiency, and severe nutritional compromise
- Theoretical mechanism not validated by large controlled trials
- Only available at specialised IPT-trained clinics
- Discuss with primary oncologist before proceeding — may conflict with standard treatment plan
- Do not use if on other blood-glucose-affecting medications without adjustment
Informational only. Not medical advice. Consult your oncologist before starting any alternative or integrative therapy.