Baking Soda / Simoncini Protocol

Key Components

• Oral sodium bicarbonate (baking soda) in water — typically 1 tsp in 8 oz water
• Alkaline diet — high vegetables, low meat, no sugar, no processed foods
• pH monitoring via urine test strips (target: slightly alkaline 7.3–7.4 urine)
• In the original Simoncini protocol: IV or catheter-administered sodium bicarbonate directly into tumours
• Avoidance of all sugar (claimed to feed Candida and cancer)

How It Works

Proponents claim tumours create an acidic microenvironment that promotes their growth. Sodium bicarbonate may neutralise this acidity and slow cancer progression. A small body of research shows that alkalising the tumour microenvironment can reduce certain cancer cell behaviours (metastasis, drug resistance). However, the blood tightly regulates pH through the kidneys and lungs — oral bicarbonate does not measurably alkalise the blood. The Candida-cancer theory has no scientific support.

Preclinical studies have shown that sodium bicarbonate can reduce metastasis in mouse models by alkalising the tumour microenvironment. However, human clinical trials are very limited. A Phase I/II trial at Moffitt Cancer Centre found oral bicarbonate to be safe and to raise urine pH, but tumour alkalisation was not confirmed. The Candida hypothesis and the broader Simoncini claims are not supported by evidence. Mainstream oncology does not endorse this as a treatment.

• Excessive sodium bicarbonate can cause metabolic alkalosis — potentially life-threatening
• Can interact with medications including chemotherapy agents
• High sodium load problematic for kidney disease, heart failure, or hypertension
• The Simoncini IV protocol has caused patient deaths — do not attempt
• Delays in starting conventional treatment can be dangerous
• NEVER use as a replacement for conventional cancer treatment